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  • Writer's pictureFulvic Med

Guard-Ion Immune Support & Ursolic acid

The Rosemary, Thyme, Oregano, Holy Basil, Sage, and Self-heal found in Guard-Ion Immune Support all have been reported to contain a very special and healing compound called Ursolic acid.

Ursolic acid has many pharmacological effects, including antioxidant, anti-inflammatory, antibacterial, antiviral, and antifungal properties. But, it’s benefits extend far beyond just reducing inflammation and fighting pathogens.

In vitro study shows that ursolic acid inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, and may also decrease proliferation of cancer cells and induce apoptosis. Ursolic acid has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation.

Ursolic acid is a weak aromatase inhibitor, and has been shown to increase the amount of muscle and brown fat and decrease white fat obesity and associated conditions when added to diets fed to mice. Under physiological concentrations, ursolic acid also induces eryptosis (the apoptosis-like suicidal cell death in defective red blood cells). It has been found to reduce muscle atrophy and to stimulate muscular growth in mice, also shows a potential cardioprotection.

In mice, ursolic acid induces neural regeneration after sciatic nerve injuries and recently found to have viral preventative capabilities. More research in this recent finding is underway.

In mice with chronic multiple sclerosis, ursolic acid has reduced further damage to neurons and helped rebuild the protective sheaths covering neurons, apparently by suppressing Th17 immune cells and activating precursor cells that mature into myelin-sheath-making cells, called oligodendrocytes.

Ursolic acid improves domoic acid-induced cognitive deficits in mice. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice.

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways.

Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.

Ursolic acid enhances mouse liver regeneration after partial hepatectomy.

Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet.

Ursolic acid increased skeletal muscle mass, as well as grip strength and exercise capacity, improved endurance, reduced the expression of the genes involved in the development of muscle atrophy, and decreased indicators of accumulated fatigue and exercise-induced stress.

In rats, ursolic acid ameliorated high-fat diet-induced hepatic steatosis and improved metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease.

Other Studies:

Effects of Ursolic Acid on Intestinal Health and Gut Bacteria Antibiotic Resistance in Mice

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Moreover, UA can be used as an alternative medicine for the treatment and prevention of cancer, obesity/diabetes, cardiovascular disease, brain disease, liver disease, and muscle wasting (sarcopenia). In this review, we have summarized recent data on the beneficial effects and possible uses of UA in health and disease managements.

Studies indicate that UA through overexpression of anti-aging biomarkers such as sirtuin (SIRT) 1, SIRT6 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha/beta (PGC-1α/β), Klotho, and orexin-A through mechanisms in the brain, skeletal muscle, liver and kidney ameliorates aging and thereby confers broad health benefits in rodents, primates and possibly human. Taken together, our recent findings advantageously described that UA mimics short-term caloric restriction, exercise and has a potential therapy for age-related diseases.

Ursolic acid alleviates hypercholesterolemia and modulates the gut microbiota

Dietary supplementation with ursolic acid, a triterpenoid with anti-inflammatory properties, attenuates monocyte dysfunction and macrophage recruitment and protects diabetic mice from atherosclerosis.

Ursolic acid inhibits cell migration and promotes JNK-dependent lysosomal associated cell death in Glioblastoma multiforme cells

Ursolic acid reduces inflammation and fibrosis in the kidney of diabetic mice

Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway

Ursolic Acid and Chronic Disease: An Overview of UA’s Effects On Prevention and Treatment of Obesity and Cancer

Ursolic Acid Inhibits the Growth of Colon Cancer-initiating Cells by Targeting STAT3

UA is an effective alternative remedy used for various cancers, obesity, diabetes, cardiovascular disease, brain disease, liver disease, osteoporosis, gastrointestinal disease and muscle wasting

Myelin Protection by Ursolic Acid in Cuprizone-Induced Demyelination in Mice

Ursolic Acid Enhances Myelin Repair in Adult Mice Brains and Stimulates Exhausted Oligodendrocyte Progenitors to Remyelinate

Ursolic Acid Ameliorates Spinal Cord Injury in Mice by Regulating Gut Microbiota and Metabolic Changes

The Biochemistry of Ursolic Acid: A Potential Therapeutic for Neuro-Inflammation

A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

Myelin Repair And Regrowth Supplement Ursolic Acid

MASSIVE benefits folks…MASSIVE!


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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